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[Immunity status in patients with injuries and diseases of the cornea]

M M Dronov, Iu I Pirogov

    Vestnik Oftalmologii
    |May 1, 1991
    PubMed

    Insights

    Immunity disorders are common in leukoma, regardless of cause. Pre-keratoplasty treatment should involve immune testing, particularly the leukocyte migration inhibition test with corneal antigen.

    Area of Science:

    • Ophthalmology
    • Immunology

    Background:

    • Leukoma, a corneal opacity, can result from injuries or diseases.
    • Immunity disorders are frequently observed in patients with leukoma.

    Purpose of the Study:

    • To investigate the presence and nature of immunity disorders in patients with leukoma.
    • To identify informative immunologic tests for preoperative assessment before keratoplasty.

    Main Methods:

    • Clinical and immunologic examinations were performed on 97 patients with leukoma.
    • The leukocyte migration inhibition test using corneal antigen was evaluated for its informativeness.

    Main Results:

    • Clinical and immunologic examinations confirmed immunity disorders in leukoma patients, irrespective of the underlying cause.
    • The leukocyte migration inhibition test with corneal antigen was identified as a highly informative immunologic test.

    Conclusions:

    • Immunity disorders are a significant factor in leukoma development and progression.
    • Preoperative assessment of immune status, utilizing tests like the leukocyte migration inhibition test, is crucial for optimizing keratoplasty outcomes.

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