Related Experiment Video

Updated: Jul 14, 2026

qPCR Is a Sensitive and Rapid Method for Detection of Cytomegaloviral DNA in Formalin-fixed, Paraffin-embedded Biopsy Tissue
08:08

qPCR Is a Sensitive and Rapid Method for Detection of Cytomegaloviral DNA in Formalin-fixed, Paraffin-embedded Biopsy Tissue

Published on: July 9, 2014

Mesenteric vein thrombosis associated with primary cytomegalovirus infection: a case report

Willem M Lijfering1, Herman G Sprenger, Willem J van Son

  • 1Division of Haemostasis, Thrombosis and Rheology, University Medical Center Groningen, Groningen, The Netherlands. w.lijfering@int.umcg.nl

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|June 22, 2007
PubMed

Insights

Cytomegalovirus infection can trigger a prothrombotic state, leading to dangerous blood clots. This case highlights a link between cytomegalovirus and mesenteric vein thrombosis in an otherwise healthy adult.

Area of Science:

  • Virology
  • Hematology
  • Thrombosis

Background:

  • Emerging evidence suggests a connection between cytomegalovirus (CMV) infection and an increased risk of thrombosis.
  • Understanding this interplay is crucial for managing patients with CMV and preventing thrombotic events.

Observation:

  • A case of primary cytomegalovirus infection in an immunocompetent adult is presented.
  • The infection was complicated by the development of mesenteric vein thrombosis.

Findings:

  • The patient exhibited transient protein C deficiency, lupus anticoagulant, and activated protein C resistance.
  • A heterozygous prothrombin G20210A mutation was also identified in the patient.
  • These factors collectively contributed to the prothrombotic state observed during the CMV infection.

Implications:

  • This case underscores the potential for cytomegalovirus to induce a prothrombotic state, even in immunocompetent individuals.
  • Further research into the mechanisms underlying CMV-related thrombosis is warranted.
  • Clinical vigilance for thrombotic complications in patients with cytomegalovirus infection is recommended.

More Related Videos

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates05:53

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

Published on: July 6, 2013

Related Concept Videos

Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Esophageal Varices-II: Clinical Features and Management01:28

Esophageal Varices-II: Clinical Features and Management

Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol abuse, or...