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Updated: Jul 14, 2026

Quantitation of Endothelial Cell Adhesiveness In Vitro
10:24

Quantitation of Endothelial Cell Adhesiveness In Vitro

Published on: June 18, 2015

Endothelial signaling by Ig-like cell adhesion molecules

Jaap D van Buul1, Edwin Kanters, Peter L Hordijk

  • 1Department of Molecular Cell Biology, Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, The Netherlands.

Arteriosclerosis, Thrombosis, and Vascular Biology
|June 23, 2007
PubMed

Insights

Leukocyte migration across blood vessels involves endothelial cell adhesion molecules (IgCAMs). These molecules initiate signaling cascades, influencing cytoskeletal changes and cell-cell contact, crucial for immune cell movement.

Area of Science:

  • Immunology
  • Cell Biology
  • Vascular Biology

Background:

  • Leukocyte migration is essential for immune response.
  • Endothelial cell adhesion molecules (IgCAMs) mediate leukocyte adhesion and transmigration.
  • Intercellular adhesion molecule-1 (ICAM-1) is a key IgCAM involved in these processes.

Purpose of the Study:

  • To review recent insights into IgCAM-driven signaling in endothelial cells.
  • To elucidate the role of IgCAM clustering in leukocyte transendothelial migration.

Main Methods:

  • Literature review of studies on leukocyte migration and endothelial cell signaling.
  • Analysis of signaling pathways initiated by IgCAM clustering.
  • Examination of cytoskeletal dynamics and cell-cell contact modulation.

Main Results:

  • IgCAM clustering triggers intracellular signaling events in endothelial cells.
  • Activation of Rho-like GTPases and cytoskeletal rearrangements are key consequences.
  • Transient modulation of endothelial cell-cell contacts facilitates leukocyte passage.

Conclusions:

  • IgCAMs are critical regulators of leukocyte transendothelial migration.
  • Understanding IgCAM-driven signaling provides insights into immune cell trafficking.
  • Targeting these pathways may offer therapeutic strategies for inflammatory diseases.

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