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Acute myeloid leukaemia presenting as galactorrhoea

M A Muslahi1, D M Ross

  • 1Department of Clinical Haematology and Bone Marrow Transplantation, Royal Adelaide Hospital, North Terrace, Adelaide, SA, Australia. almuslahimnr@hotmail.com

International Journal of Laboratory Hematology
|September 11, 2007
PubMed

Insights

A woman with acute myeloid leukemia (AML) experienced elevated prolactin levels and galactorrhea. Her prolactin normalized after chemotherapy, suggesting a paraneoplastic phenomenon.

Area of Science:

  • Hematology
  • Endocrinology
  • Oncology

Background:

  • Acute myeloid leukemia (AML) presents with diverse clinical symptoms.
  • Hyperprolactinemia, characterized by elevated prolactin levels, can have various causes.

Purpose of the Study:

  • To report a rare case of acute myeloid leukemia presenting with hyperprolactinemia.
  • To explore the potential paraneoplastic link between AML and elevated prolactin.

Main Methods:

  • Case report of a 40-year-old female patient.
  • Clinical presentation, laboratory findings (including prolactin levels), and treatment response were analyzed.

Main Results:

  • The patient presented with galactorrhea and elevated prolactin, despite normal blood counts.
  • Acute myeloid leukemia with monocytic differentiation was diagnosed.
  • Serum prolactin normalized following chemotherapy.

Conclusions:

  • Hyperprolactinemia can be an unusual presenting sign of acute myeloid leukemia.
  • The elevated prolactin in this case is presumed to be a paraneoplastic phenomenon in the absence of central nervous system involvement.

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