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t(6;14)(q15;q32) in a patient with CD5+CD10+ diffuse large B-cell lymphoma
Miyuki Hayama1, Nozomi Niitsu, Masaaki Higashihara
1Department of Hematology, Kitasato University, Sagamihara-shi, Kanagawa, Japan. mhayama@med.kitasato-u.ac.jp
Insights
This study reports a rare case of CD5-positive, CD10-positive diffuse large B-cell lymphoma in a patient with hereditary spherocytosis. The lymphoma exhibited a unique chromosomal translocation, t(6;14)(q15;q32), highlighting the need for further research into lymphomagenesis mechanisms.
Area of Science:
- Hematology
- Oncology
- Genetics
Background:
- Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin lymphoma.
- Co-occurrence of DLBCL with hereditary spherocytosis is uncommon.
- Specific immunophenotypic and cytogenetic profiles can influence DLBCL behavior and prognosis.
Observation:
- A 68-year-old male presented with systemic lymphadenopathy.
- Cervical lymph node biopsy revealed diffuse proliferation of large atypical lymphoid cells.
- Immunohistochemistry showed positivity for CD5, CD10, CD20, CD79a, and Bcl2, and negativity for CD3 and cyclin D1.
Findings:
- The patient was diagnosed with CD5+, CD10+ diffuse large B-cell lymphoma.
- Karyotypic analysis revealed complex chromosomal abnormalities, including add(5)(q13), del(6)(q13), add(17)(p11), add(19)(p11), add(19)(p13), and a non-random t(6;14)(q15;q32) translocation.
- Peripheral blood smear showed elliptocytosis, and a family history confirmed hereditary spherocytosis.
Implications:
- The presence of CD5 and CD10 markers in DLBCL, along with the specific t(6;14)(q15;q32) translocation, suggests a distinct subtype requiring further investigation.
- Understanding the lymphomagenesis mechanism in such cases is crucial for developing targeted therapies.
- The co-occurrence with hereditary spherocytosis warrants exploration of potential shared pathways or independent disease processes.
Abstract:
A 68-year-old man presented with systemic lymph node swelling. A biopsy specimen taken from the right cervical lymph node showed that the normal architecture was replaced by a diffuse proliferation of large lymphoid cells with large atypical nuclei. Immunohistochemical analysis showed that the atypical lymphoid cells were positive for CD5, CD10, CD20, CD79a, and Bcl2, and negative for CD3 and cyclin D1. A diagnosis of diffuse large B-cell lymphoma was made. Karyotypic findings included add(5)(q13), del(6)(q13), add(17)(p11), add(19)(p11), add(19)(p13), and t(6;14)(q15;q32). The serum lactate dehydrogenase level and indirect bilirubin level were slightly elevated. Elliptocytosis was observed in the peripheral blood, and a diagnosis of hereditary spherocytosis was made from the family history. Regarding CD5+CD10+ diffuse large B-cell lymphoma with a non-random chromosomal translocation of t(6;14)(q15;q32), studies on the mechanism of lymphomagenesis are needed.
