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Nuclear factor-kappa B: from clone to clinic

Kwang Seok Ahn1, Gautam Sethi, Bharat B Aggarwal

  • 1Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.

Current Molecular Medicine
|November 30, 2007
PubMed

Insights

Nuclear factor kappaB (NF-kappaB) is a key regulator of genes involved in inflammation and cell survival. Its aberrant activation is linked to various diseases, including cancer, driving research into therapeutic inhibitors.

Area of Science:

  • Molecular Biology
  • Immunology
  • Oncology

Background:

  • Nuclear factor kappaB (NF-kappaB) is a transcription factor initially identified in B cells.
  • In its resting state, NF-kappaB resides in the cytoplasm.
  • Upon activation by stimuli like inflammation or stress, it translocates to the nucleus.

Purpose of the Study:

  • To review the role of NF-kappaB in various biological processes.
  • To highlight the association of NF-kappaB activation with diverse inflammatory diseases and cancer.
  • To discuss the diagnostic, prognostic, and therapeutic potential of NF-kappaB.

Main Methods:

  • Literature review of studies on NF-kappaB.
  • Analysis of NF-kappaB's role in gene regulation.
  • Examination of NF-kappaB's involvement in disease pathogenesis.

Main Results:

  • NF-kappaB upregulates over 400 genes related to inflammation, cell survival, proliferation, invasion, and angiogenesis.
  • Constitutive NF-kappaB activation correlates with cancer progression, survival, and resistance to therapy.
  • NF-kappaB has demonstrated diagnostic and prognostic value in several conditions.

Conclusions:

  • NF-kappaB plays a critical role in cellular responses and disease development.
  • Targeting NF-kappaB is a promising therapeutic strategy for inflammatory diseases and cancer.
  • NF-kappaB research has rapidly progressed from basic discovery to clinical applications.

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