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Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

[Immunomodulation in severe leptospirosis with multiple organ failure: plasma exchange, intravenous immunoglobulin or

E Meaudre1, Y Asencio, A Montcriol

  • 1Département d'anesthésie-réanimation, hôpital d'instruction des Armées Sainte-Anne, boulevard Sainte-Anne, 83000 Toulon, France. meaudre@club-internet.fr

Annales Francaises D'Anesthesie Et De Reanimation
|December 25, 2007
PubMed

Insights

Severe leptospirosis led to multiple organ failure. Immunomodulation with methylprednisolone and immunoglobulin therapy rapidly improved this patient

Area of Science:

  • Infectious Diseases
  • Nephrology
  • Critical Care Medicine

Background:

  • Leptospirosis is a zoonotic infection that can cause severe systemic illness.
  • Multiple organ failure syndrome (MOFS) is a life-threatening complication of severe infections.

Observation:

  • A 62-year-old patient presented with symptoms of severe leptospirosis, including fever, asthenia, myalgias, acute renal failure, hyperbilirubinemia, rhabdomyolysis, and thrombocytopenia.
  • Despite initial treatment with amoxicillin and continuous veno-venous hemodiafiltration, the patient's condition worsened, developing acute respiratory distress syndrome (ARDS) and increased hyperbilirubinemia.

Findings:

  • Administration of methylprednisolone and intravenous immunoglobulin resulted in rapid clinical and biological improvement.
  • This case highlights the potential benefit of immunomodulatory therapy in severe leptospirosis with MOFS.

Implications:

  • Early recognition and aggressive management, including immunomodulation, may be crucial for improving outcomes in severe leptospirosis.
  • Further research into the role of immunomodulation in leptospirosis is warranted.

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