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[Immunohistochemical study of temporomandibular joint disturbance syndrome]
1School of Stomatology, Beijing Medical University.
Insights
Autoimmune responses occur in temporomandibular joint disturbance syndrome (TMJDS) articular tissues. These responses, triggered by exposed antigens within the joint, may contribute to TMJ destruction.
Area of Science:
- Immunology
- Rheumatology
- Oral and Maxillofacial Surgery
Abstract:
In this paper, condylar cartilages of 10 temporomandibular joint disturbance syndrome (TMJDS) patients were studied by means of immunofluorescence and immunogold staining to clarify if there are immune complexes. We also detected the antibodies to type II collagen in synovial fluids and sera of the TMJDS patients with passive hemagglutination. Through these studies, we found: there are autoimmune responses in articular tissues in TMJDS; these responses are caused by the exposure of sequestered antigens and taken place mainly in the involved joints, and may participate in the destruction of TMJ.