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Updated: Jul 8, 2026

Manipulating the Murine Lacrimal Gland
05:56

Manipulating the Murine Lacrimal Gland

Published on: November 18, 2014

Extramedullary hematopoiesis in the lacrimal gland

Roman Shinder1, Neena Mirani, Hen-Vai Wu

  • 1Institute of Ophthalmology and Visual Sciences, New Jersey Medical School, Newark, New Jersey 07103, USA

Ophthalmic Plastic and Reconstructive Surgery
|January 23, 2008
PubMed

Insights

Extramedullary hematopoiesis rarely affects lacrimal glands in patients with chronic myeloid leukemia. This condition can cause eyelid swelling and enlarged lacrimal glands, requiring further investigation.

Area of Science:

  • Ophthalmology
  • Hematology
  • Oncology

Background:

  • Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm.
  • Extramedullary hematopoiesis (EMH) is the formation of blood cells outside bone marrow.
  • EMH in lacrimal glands is an exceptionally rare manifestation.

Observation:

  • A 61-year-old woman with CML presented with bilateral eyelid edema.
  • Orbital MRI revealed enlarged lacrimal glands.
  • Biopsy confirmed extramedullary hematopoiesis within the lacrimal gland.

Findings:

  • Lacrimal gland biopsy demonstrated hematopoietic cells, precursors, and megakaryocytes.
  • These findings are consistent with extramedullary hematopoiesis.
  • This indicates a rare site of CML manifestation.

Implications:

  • Highlights the importance of considering EMH in myeloproliferative neoplasms presenting with orbital symptoms.
  • Suggests lacrimal gland biopsy as a diagnostic tool for unusual CML complications.
  • Underscores the diverse clinical presentations of CML beyond typical hematologic findings.

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