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[The immunological diagnosis of tuberculosis]
Insights
Immunofermental analysis (IFA) shows high accuracy for diagnosing tuberculosis. This serological method is recommended for practical use in clinics for effective tuberculosis detection.
Area of Science:
- Immunology
- Infectious Diseases
- Medical Diagnostics
Context:
- Tuberculosis diagnosis relies on various serological methods.
- Accurate and efficient diagnostic tools are crucial for patient management.
- Literature review highlights the need for effective serological diagnostics.
Purpose:
- To evaluate the efficacy of immunofermental analysis (IFA) for tuberculosis serological diagnostics.
- To determine diagnostic titers for pulmonary and non-pulmonary tuberculosis using IFA.
- To compare IFA results in tuberculosis patients, non-tuberculosis patients, and healthy donors.
Summary:
- Immunofermental analysis (IFA) using a phosphide antigen demonstrated high diagnostic value.
- Established minimum diagnostic titers: 1:320 for pulmonary TB, 1:160 for non-pulmonary TB.
- Mean antigen titers varied significantly between TB patients (0.92-1.32) and controls (0.20-0.25).
Impact:
- IFA is recommended for practical application in tuberculosis and infectious disease clinics.
- This method offers a reliable approach for serological detection of tuberculosis.
- The findings support the integration of IFA into routine diagnostic workflows.
Abstract:
On the basis of literature review the article makes an appreciation of various methods for tuberculosis serological diagnostics. The authors mark a high information level of immunofermental analysis (IFA). 126 tuberculosis patients, 122 patients with non-tuberculosis etiology and 410 donors were examined with the aid of IFA (phosphide antigen). The min. diagnostic titer in pulmonary tuberculosis is 1:320, in nonpulmonary--1:160. The max. antigen titers in IFA (optical density unit of measurement) were in the cases of disseminated tuberculosis 1.32 0.12; the min.--in uterine tube tuberculosis--0.92 0.08. The titers of donors were 0.20 0.03, and of patients with non-tuberculosis diseases--0.25 0.04. IFA is recommended for practical application in tuberculosis and infectious clinics.