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Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
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[Inhibitor effect of CD8+CD57+ lymphocytes on cell-mediated cytotoxicity: characterization of suppressor factor]

B Autran1, B Sadat-Sowti, P Debre

  • 1Laboratoire d'Immunologie cellulaire et tissulaire, U.A.-C.N.R.S. n. 186, Paris.

Comptes Rendus De L'Academie Des Sciences. Serie III, Sciences De La Vie
|January 1, 1991
PubMed

Insights

CD8+CD57+ lymphocytes from HIV patients and transplant recipients suppress immune cell activity. This inhibition is mediated by a heat-resistant, glycosylated soluble factor of 20-30 kD.

Area of Science:

  • Immunology
  • Cell Biology

Context:

  • Human Immunodeficiency Virus (HIV) infection
  • Organ transplantation
  • Immune system regulation

Purpose:

  • Investigate the function of CD8+CD57+ lymphocytes
  • Identify novel immunosuppressive mechanisms

Summary:

  • CD8+CD57+ lymphocytes from HIV-seropositive patients and allotransplanted recipients exhibit a suppressor function.
  • This function inhibits the cytolytic activity of allospecific cytotoxic T lymphocytes (CTL), natural killer (NK) cells, and lymphokine-activated killer (LAK) cells.
  • The inhibitory effect is mediated by a non-antigen specific soluble factor, distinct from known mediators like PGE2, TGF-β, and TNF-α/β.
  • Preliminary characterization reveals the factor is heat and trypsin resistant, binds to Concanavalin A (suggesting glycosylation), and has a molecular weight of 20-30 kDa.

Impact:

  • Elucidates a novel immunosuppressive mechanism involving CD8+CD57+ lymphocytes.
  • Potential implications for understanding immune dysregulation in HIV and post-transplant settings.
  • Identifies a novel soluble factor with potential therapeutic or diagnostic applications.

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