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[Uncommon cystic appearance of lymph nodes in malignant lymphoma]

A Hollerweger1, P Macheiner, D Neureiter

  • 1Radiologie und Nuklearmedizin, KH Barmherzige Brüder, Salzburg. alois.hollerweger@bbsalz.at

Ultraschall in Der Medizin (Stuttgart, Germany : 1980)
|June 3, 2008
PubMed

Insights

Mantle cell lymphoma with cystic transformation was diagnosed in a patient presenting with weight loss and rectal bleeding. Ultrasound revealed cystic lymph nodes, confirmed by biopsy and immunological markers.

Area of Science:

  • Oncology
  • Pathology
  • Radiology

Background:

  • Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin B-cell lymphoma.
  • Lymphadenopathy is a common clinical manifestation of MCL.
  • Cystic changes in lymph nodes can occur in various conditions, including lymphomas.

Observation:

  • Sonographic examination of a patient with unexplained weight loss and rectal bleeding revealed enlarged superficial lymph nodes.
  • These lymph nodes exhibited numerous partially cystic areas on ultrasound.
  • The presence of cystic changes prompted further investigation.

Findings:

  • Histopathological examination of biopsied lymph nodes confirmed mantle cell lymphoma.
  • Immunohistochemical staining revealed specific immunological markers consistent with MCL.
  • Additional staining confirmed the cystic transformation of the lymph node sinuses, a less common presentation of MCL.

Implications:

  • This case highlights the importance of considering lymphoma, specifically mantle cell lymphoma, in the differential diagnosis of cystic lymphadenopathy.
  • Sonographic findings of cystic lymph nodes in patients with constitutional symptoms warrant thorough histopathological evaluation.
  • Understanding the sonographic and histological features of cystic transformation in MCL can aid in earlier diagnosis and management.

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