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Nerve growth factor receptor expression on dendritic reticulum cells in follicular lymphoid proliferations

R S Strobach1, H Nakamine, A S Masih

  • 1Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198.

Human Pathology
|May 1, 1991
PubMed

Insights

Nerve growth factor receptor (NGFR) is typically present on dendritic reticulum cells (DRCs) in normal lymph nodes. Most follicular lymphomas show a loss of NGFR expression, suggesting DRCs are altered in this cancer.

Area of Science:

  • Immunohistochemistry
  • Lymphoma Research
  • Cell Biology

Background:

  • Dendritic reticulum cells (DRCs) are crucial components of lymph node architecture.
  • The role of NGFR in DRC function and lymphomagenesis is not fully understood.

Purpose of the Study:

  • To investigate the expression of NGFR on DRCs in reactive lymph nodes and various lymphomas.
  • To determine if NGFR expression changes in follicular lymphoma.

Main Methods:

  • Immunohistochemical analysis of 62 lymph node samples.
  • Utilized an antibody targeting the nerve growth factor receptor (NGFR).
  • Examined formalin-fixed, paraffin-embedded tissues from patients with reactive follicular hyperplasia and lymphomas.

Main Results:

  • A dendritic staining pattern for NGFR was observed in most reactive lymph nodes (25/26).
  • In contrast, only a small subset of follicular lymphomas (3/28) showed NGFR staining within neoplastic follicles.
  • Benign germinal centers in mantle zone lymphoma and Hodgkin's disease retained NGFR expression.

Conclusions:

  • NGFR may play a role in the maturation and/or activation of normal DRCs.
  • The loss of NGFR expression in follicular lymphomas suggests alterations in DRCs during neoplastic transformation.
  • DRCs may be involved in the pathogenesis of follicular lymphoma.

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