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A condition resembling pagetoid reticulosis in a laboratory mouse
D P Abbott1, M T Masson, M C Bonnet
1Centre de Recherche, Laboratoires Pfizer, Amboise, France.
Insights
A rare cutaneous lymphoid neoplasm, resembling pagetoid reticulosis, was identified in a mouse. This finding is characterized by specific cellular infiltration and nuclear abnormalities, with no prior reports in mice.
Area of Science:
- Veterinary Pathology
- Dermatopathology
- Oncology
Background:
- Cutaneous lymphoid neoplasms are rare in mice.
- Pagetoid reticulosis is an epidermotropic T-cell lymphoma characterized by specific cellular morphology.
Purpose of the Study:
- To describe a novel cutaneous lymphoid neoplasm in a mouse.
- To characterize the histological features and cellular morphology of the observed lesion.
Main Methods:
- Necropsy and histological examination of a CD1 mouse.
- Morphological assessment of cutaneous infiltrates, including cellular size, nuclear features, and epidermal infiltration.
Main Results:
- A raised, hairless cutaneous nodule was identified.
- Histology revealed epidermal infiltration by monomorphic, moderate to large lymphocytoid cells.
- Many cells exhibited bizarre nuclear convolutions, resembling Sézary or mycosis cells, characteristic of pagetoid reticulosis.
Conclusions:
- The observed lesion represents a potential case of pagetoid reticulosis in a mouse.
- This is the first reported instance of such a cutaneous lymphoid neoplasm in the murine model.
- Further research is warranted to understand the pathogenesis and implications of this condition in mice.
Abstract:
A raised, hairless cutaneous nodule was found incidentally at necropsy of a 24-month-old CD1 mouse. Histologically there was infiltration of the epidermis by a monomorphic population of moderate to large lymphocytoid cells. Many large cells had bizarre convolutions of the nuclear membrane and resembled the so-called Sézary or mycosis cells seen in epidermotropic T-cell proliferative disorders. The pattern of cutaneous involvement and the presence of the large cells with convoluted nuclei is characteristic of pagetoid reticulosis. No previous reports of such cutaneous lymphoid neoplasms in mice were found in an extensive literature search.
