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Epithelioid cells in mediastinal lymph nodes of cattle without cancer

M Komine1, K Kawasako, M Okamoto

  • 1Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, 582-1 Bunkyodai-Midorimachi, Ebetsu, Hokkaido 069-8501, Japan.

Veterinary Pathology
|January 30, 2009
PubMed

Insights

Benign epithelioid cells, likely mesothelial in origin, were incidentally found in bovine lymph nodes. These cells did not indicate cancer and appeared to enter via lymphatic vessels.

Area of Science:

  • Veterinary Pathology
  • Bovine Lymph Node Histology

Background:

  • Epithelioid cells in lymph nodes often suggest metastatic carcinoma.
  • Benign epithelioid cells have been incidentally observed in lymph nodes.

Purpose of the Study:

  • To investigate the prevalence and characteristics of epithelioid cells found in bovine mediastinal lymph nodes.
  • To determine the origin and significance of these epithelioid cells in cattle without cancer.

Main Methods:

  • Retrospective analysis of 110 bovine mediastinal lymph nodes.
  • Histopathologic, immunohistochemical, and ultrastructural examinations were performed.

Main Results:

  • Epithelioid cells were identified in 66 out of 110 lymph nodes.
  • Immunohistochemistry and ultrastructural analysis suggested a mesothelial origin for most epithelioid cells.
  • Cells were found individually, aggregated in sinuses, and occasionally in tubular structures, often within afferent lymphatic vessels.

Conclusions:

  • The epithelioid cells observed in bovine lymph nodes were likely benign mesothelial cells, not indicative of metastatic carcinoma.
  • These cells appear to migrate into lymph nodes via lymphatic vessels.
  • Their presence does not disrupt lymph node architecture or suggest malignancy.

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