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[A case of pulmonary MALT lymphoma with 6-year natural history]

Miki Satoh1, Osamu Wakabayashi, Eisei Jinushi

  • 1Department of Respiratory Medicine, National Hospital Organization, Hakodate Hospital.

Nihon Kokyuki Gakkai Zasshi = the Journal of the Japanese Respiratory Society
|February 7, 2009
PubMed

Insights

A rare case of primary pulmonary B-cell lymphoma (MALT type) was diagnosed in a 58-year-old man. This slow-growing lung cancer showed a complete response to Rituximab-CHOP therapy.

Area of Science:

  • Oncology
  • Pulmonology
  • Hematology

Background:

  • Primary pulmonary lymphoma is a rare extranodal non-Hodgkin lymphoma.
  • Mucosa-associated lymphoid tissue (MALT) lymphoma can occur in the lung, often presenting insidiously.

Observation:

  • A 58-year-old man presented with an incidental abnormal shadow on chest X-ray.
  • Chest CT revealed an infiltrative shadow with an air-bronchogram in the right upper lobe.
  • Retrospective review showed slow growth of lung shadows over 6 years.

Findings:

  • Biopsy and gene analysis confirmed primary pulmonary B-cell lymphoma of MALT type, specifically t(11;18)/API2-MALT1.
  • Immunohistochemical examination aided in the definitive diagnosis.
  • The patient achieved a complete response following Rituximab-CHOP therapy.

Implications:

  • This case highlights the importance of considering rare diagnoses like pulmonary MALT lymphoma in patients with persistent lung shadows.
  • Early detection and accurate molecular diagnosis are crucial for effective treatment.
  • Rituximab-CHOP therapy demonstrates efficacy in treating this specific subtype of pulmonary lymphoma.

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