Related Experiment Video

Updated: Jun 25, 2026

Isolation of CD4+ T-cells and Analysis of Circulating T-follicular Helper (cTfh) Cell Subsets from Peripheral Blood Using 6-color Flow Cytometry
07:39

Isolation of CD4+ T-cells and Analysis of Circulating T-follicular Helper (cTfh) Cell Subsets from Peripheral Blood Using 6-color Flow Cytometry

Published on: January 7, 2019

Idiopathic CD4+ T-cell lymphocytopenia

Aparna Mukherjee1, Rakesh Lodha, S K Kabra

  • 1Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.

Indian Journal of Pediatrics
|February 12, 2009
PubMed

Insights

Idiopathic CD4+ T lymphocytopenia (ICL) is a rare immune disorder causing low CD4+ T cells and opportunistic infections. This report details two ICL cases with opportunistic infections, highlighting the condition

Area of Science:

  • Immunology
  • Infectious Diseases

Background:

  • Idiopathic CD4+ T lymphocytopenia (ICL) is a rare immune deficiency characterized by a significant reduction in CD4+ T cells.
  • This condition predisposes individuals to severe opportunistic infections due to impaired cellular immunity.

Observation:

  • Two cases of ICL are presented, both exhibiting a low CD4+ T cell count or percentage.
  • Patients presented with a range of opportunistic infections, including candidiasis, cytomegalovirus, and Mycobacterium tuberculosis.

Findings:

  • The presented cases underscore the diagnostic challenge and clinical severity associated with ICL.
  • The opportunistic infections observed are consistent with profound cellular immune deficiency.

Implications:

  • Early recognition and diagnosis of ICL are crucial for timely management and prevention of life-threatening infections.
  • Further research into the pathogenesis and treatment of ICL is warranted to improve patient outcomes.

More Related Videos

Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.08:11

Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.

Published on: September 1, 2015

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis11:28

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis

Published on: March 25, 2016

Related Concept Videos

Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...