Diffuse large B-cell lymphoma: experience from a tertiary care center in North India

Area of Science:

• Hematology
• Oncology
• Clinical Pathology

Background:

• Limited data exists on diffuse large B-cell lymphoma (DLBCL) presentation in developing nations.
• Understanding clinico-pathological characteristics is crucial for improving patient outcomes.

Purpose of the Study:

• To investigate the clinico-laboratory features, treatment outcomes, and prognostic factors of DLBCL.
• To analyze the distribution and characteristics of other non-Hodgkin's lymphoma (NHL) subtypes.
• To compare NHL presentation in the Indian population with developed countries.

Main Methods:

• Retrospective case record study of non-Hodgkin's lymphoma (NHL) patients.
• Analysis of demographic data, clinical presentation, Ann Arbor stage, and International Prognostic Index (IPI).
• Evaluation of laboratory parameters including hemoglobin, platelet count, albumin, and erythrocyte sedimentation rate.

Main Results:

• Diffuse large B-cell lymphoma (DLBCL) was the predominant NHL subtype (59.3%).
• Median age at presentation for DLBCL was 47 years, with a male to female ratio of 2.7:1.
• Significant differences in hemoglobin, platelet count, albumin, and ESR were observed between favorable and unfavorable IPI groups, indicating their prognostic value.
• Median event-free survival was 32 months and overall survival was 47 months.
• NHL in the Indian population presented with earlier onset, a male predominance, and more frequent B symptoms compared to developed countries.

Conclusions:

• DLBCL is the most common NHL subtype in this population, with distinct demographic and clinical features.
• Laboratory parameters like hemoglobin, platelet count, albumin, and ESR are significant prognostic markers for DLBCL.
• NHL in India exhibits unique characteristics compared to Western populations, necessitating tailored management strategies.