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Infectious imaging with indium-111-labeled nonspecific polyclonal human immunoglobulin

W A Wegener1, M G Velchik, D Weiss

  • 1Department of Radiology, University of Pennsylvania, Philadelphia 19104.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|November 1, 1991
PubMed

Insights

Indium-111 labeled immunoglobulin G (111In-IgG) shows promise as a superior imaging agent for detecting focal infections and inflammation. This study confirms its effectiveness and practical advantages over other imaging methods.

Area of Science:

  • Nuclear Medicine
  • Diagnostic Imaging
  • Immunology

Background:

  • Nonspecific polyclonal immunoglobulin G (IgG) labeled with Indium-111 (111In-IgG) has demonstrated potential for infection and inflammation detection.
  • Previous reports suggest 111In-IgG is comparable to antigen-specific antibodies in early imaging (within 24 hours).

Purpose of the Study:

  • To evaluate the clinical utility and diagnostic accuracy of 111In-IgG in a Phase II study.
  • To compare the efficacy of 111In-IgG with established imaging agents like 67Ga-citrate and 111In-labeled leukocytes.

Main Methods:

  • A Phase II clinical study involving 15 patients with suspected focal infection or inflammation.
  • Diagnostic confirmation through pathological examination, clinical assessment, laboratory results, and other imaging modalities.
  • Analysis of imaging results for accuracy, including false-positives and false-negatives.

Main Results:

  • 111In-IgG demonstrated high accuracy in identifying focal infection/inflammation.
  • The study reported 10 confirmed positives and 4 confirmed negatives, with no false-positive results.
  • One potential false-negative case was noted in suspected aspiration pneumonia.

Conclusions:

  • 111In-IgG is a valuable imaging agent for detecting infection and inflammation.
  • It offers practical advantages over 67Ga-citrate and 111In-labeled leukocytes.
  • Further research supports the use of 111In-IgG in clinical practice for diagnosing infectious and inflammatory conditions.

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