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[T-cell type non-Hodgkin's lymphoma associated with eosinophilia]

M Matsuzaki1, Y Shimamoto, T Tokioka

  • 1Department of Internal Medicine, Saga Medical School.

[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|August 1, 1991
PubMed

Insights

This study reports a rare case of non-Hodgkin's lymphoma presenting with severe hypereosinophilia. Chemotherapy effectively resolved both the lymphoma and the eosinophilia, suggesting a potential link.

Area of Science:

  • Hematology
  • Oncology

Background:

  • Non-Hodgkin's lymphoma (NHL) is a diverse group of lymphoid malignancies.
  • Hypereosinophilia, characterized by elevated eosinophil counts, can be associated with various conditions, including malignancies.

Observation:

  • A 65-year-old male presented with generalized lymphadenopathy and marked leukocytosis (40,900/microliters) with 88% eosinophils.
  • Bone marrow examination revealed increased eosinophils and precursors without other abnormalities.
  • Biopsy confirmed diffuse, medium-sized cell non-Hodgkin's lymphoma with lymphoma cell infiltration in the stomach.

Findings:

  • Extensive investigations failed to identify an etiology for the patient's hypereosinophilia.
  • Combination chemotherapy led to a dramatic resolution of both the eosinophilia and lymphadenopathy.
  • The patient's marker analysis was CD3+4+8-, and human T-lymphotropic virus type I antibody was negative.

Implications:

  • This case highlights the unusual association between hypereosinophilia and non-Hodgkin's lymphoma.
  • It suggests that lymphoma should be considered in the differential diagnosis of unexplained hypereosinophilia.
  • The prompt response to chemotherapy indicates a potential paraneoplastic or direct effect of the lymphoma on eosinophil production.

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