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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

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Lymphoproliferative disease of the kidney developing in fibro-inflammatory lesion

Yumiko Hori1, Naoki Wada, Masaharu Kohara

  • 1Department of Pathology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan.

Pathology, Research and Practice
|June 2, 2009
PubMed

Insights

This study reports a rare case of Epstein-Barr virus-positive B-cell lymphoproliferative disease (B-LPD) within an inflammatory pseudotumor (IPT) of the kidney. This is the first documented instance of B-LPD in renal IPT and the initial detection of EBV in renal lymphoma cells.

Area of Science:

  • Oncology
  • Pathology
  • Virology

Background:

  • Inflammatory pseudotumor (IPT) is a rare, non-neoplastic lesion that can occur in various organs, including the kidney.
  • Renal IPTs are typically benign but can mimic malignant tumors, posing diagnostic challenges.
  • The association of IPT with lymphoproliferative disorders (LPDs) is uncommon.

Observation:

  • An 80-year-old male presented with fever and night sweats, found to have a renal mass on CT scan.
  • Surgical resection revealed a renal lesion characterized by fibrous tissue, lymphoid cells, and minute nodules.
  • Histological examination identified large lymphoid cells positive for CD20 and containing the Epstein-Barr virus (EBV) genome.

Findings:

  • The diagnosis was EBV-positive B-cell lymphoproliferative disease (B-LPD) arising within a renal inflammatory pseudotumor (IPT).
  • This represents the first reported case of B-LPD occurring in the context of a renal IPT.
  • The presence of EBV within renal lymphoma cells is a novel finding.

Implications:

  • This case expands the spectrum of B-LPD and IPT presentations.
  • It highlights the importance of thorough histopathological evaluation for accurate diagnosis of renal masses.
  • Further research may elucidate the role of EBV in the pathogenesis of renal IPT-associated LPDs.

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