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Lymphoplasmacytoid lymphoma in a cow

Hidetsugu Honda1, Yoshiharu Ishikawa, Koichi Kadota

  • 1Agricultural Technology Division, Toyama Prefecture, Toyama, Japan.

The Journal of Veterinary Medical Science
|June 6, 2009
PubMed

Insights

A rare lymphoplasmacytoid lymphoma was identified in a cow lacking bovine leukemia virus (BLV). This finding differs from typical BLV-associated lymphomas, suggesting alternative pathways for B-cell lymphomagenesis in cattle.

Area of Science:

  • Veterinary Pathology
  • Bovine Oncology
  • Immunology

Background:

  • Lymphoplasmacytoid lymphoma (LPL) is a rare B-cell neoplasm.
  • Bovine leukemia virus (BLV)-associated lymphoma is common in cattle.
  • This case presents LPL in a BLV-negative Holstein cow.

Observation:

  • An 8-year-old Holstein cow presented with neoplastic tissue.
  • The tissue contained lymphoid and plasmacytoid cells with intracytoplasmic IgM (lambda).
  • CD5 expression was noted on small lymphoid cells.

Findings:

  • The diagnosis of lymphoplasmacytoid lymphoma was established.
  • Histological features suggested progression towards immunoblastic lymphoma.
  • Neoplastic cell differentiation differed from BLV-associated pleomorphic lymphoma.

Implications:

  • This case highlights a distinct form of lymphoma in cattle.
  • It suggests BLV is not essential for all B-cell lymphomas in this species.
  • Further research into non-BLV lymphomagenesis in cattle is warranted.

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