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[CD4-positive diffuse large B-cell lymphoma]
Tomonori Nakazato1, Kazuhito Suzuki, Ai Mihara
1Department of Hematology/Oncology, Yokohama Municipal Citizen's Hospital.
Insights
This study reports the first case of CD4-positive diffuse large B-cell lymphoma (DLBCL) in an 82-year-old man. The patient achieved complete remission after R-CHOP treatment for this rare DLBCL subtype.
Area of Science:
- Hematology
- Oncology
- Immunophenotyping
Background:
- Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin lymphoma.
- Accurate diagnosis relies on detailed immunophenotypic analysis.
- CD4 positivity is an unusual finding in DLBCL.
Observation:
- An 82-year-old male presented with lymphadenopathy after lung cancer surgery.
- Biopsy revealed diffuse large B-cell lymphoma.
- Immunophenotyping showed CD4 and CD19 co-expression on lymphoma cells.
Findings:
- The patient was diagnosed with a rare CD4-positive DLBCL.
- Treatment with R-CHOP resulted in complete remission.
- This represents the first reported case of CD4-positive DLBCL.
Implications:
- Highlights the importance of comprehensive immunophenotyping for DLBCL subtyping.
- Suggests CD4-positive DLBCL may be a distinct entity.
- Further research is needed to understand the biology and optimal treatment of this rare subtype.
Abstract:
An 82-year-old man received right upper lobectomy for lung cancer in April 2006. In August, 2006, he was readmitted to our hospital due to left cervical and left inguinal lymph node swelling. A pathologic diagnosis of diffuse large B-cell lymphoma (DLBCL) was made from a biopsy specimen of the left cervical lymph node. The immunophenotype of the lymphoma cells was CD2-, sCD3-, cCD3-, CD4+, CD5+, CD7-, CD8-, CD10-, CD19+, CD20+, CD23+, CD25+, kappa+, lambda-, CD56-, and dual staining confirmed that the cells were positive for both CD4 and CD19. From these findings, he was diagnosed with CD4-positive DLBCL. Five cycles of R-CHOP were performed and complete remission was achieved. To our knowledge, this is the first report of CD4-positive DLBCL.
