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Cyclin D1 positive follicular lymphoma

B Olsen1, G Srkalovic, M Law

  • 1Ingham Regional Medical Center, Lansing, Michigan 48910, USA. brian.olsen@irmc.org

Journal of Clinical Pathology
|September 8, 2009
PubMed

Insights

This case report details a rare follicular lymphoma with unusual cyclin D1 expression. Genetic analysis revealed BCL2-IGH and CCND1-IGH fusions, offering insights into lymphoma subtypes.

Area of Science:

  • Hematology
  • Oncology
  • Molecular Pathology

Background:

  • Follicular lymphoma is typically characterized by BCL2 gene rearrangement.
  • Cyclin D1 expression is uncommon in low-grade follicular lymphoma.

Observation:

  • An unusual case of low-grade follicular lymphoma exhibiting cyclin D1 expression was observed.
  • Standard histological features of follicular lymphoma were present.

Findings:

  • Interphase fluorescence in situ hybridisation (FISH) identified both BCL2-IGH and CCND1-IGH fusions.
  • The co-occurrence of these genetic alterations is noteworthy.

Implications:

  • This case expands the molecular understanding of follicular lymphoma heterogeneity.
  • It may inform diagnostic approaches and classification of B-cell lymphomas.
  • Further research into the clinical significance of combined BCL2 and CCND1 fusions is warranted.

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