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THE VALUE OF MALLORY'S CONNECTIVE TISSUE STAIN FOR THE DEMONSTRATION OF VARIATION IN THYROID COLLOID

A P Jones1

  • 1Pathological Department of the University of Wisconsin, Madison.

The Journal of Experimental Medicine
|October 30, 2009
PubMed

Insights

Mallory

Area of Science:

  • Histology and Biochemistry
  • Thyroid Physiology

Background:

  • The thyroid gland's colloid stores iodine, crucial for hormone synthesis.
  • Understanding iodine dynamics in the thyroid is vital for metabolic research.

Purpose of the Study:

  • To evaluate Mallory's stain for detecting thyroid colloid iodine.
  • To investigate the relationship between heart activity and thyroid iodine levels.

Main Methods:

  • Utilized Mallory's connective tissue stain with Zenker's fluid or bichloride of mercury fixation.
  • Correlated staining results with chemical iodine determinations, iodine feeding studies, and in vitro experiments.

Main Results:

  • Mallory's stain effectively demonstrates the presence or absence of iodine in thyroid colloid.
  • Increased heart activity correlated with a significant loss of thyro-iodine from the thyroid colloid.

Conclusions:

  • Mallory's stain is a viable method for assessing thyroid iodine content in experimental settings.
  • Thyroid iodine levels are inversely related to cardiac activity, suggesting a physiological link.
  • The technique shows potential for future thyroid research, though not immediately for clinical application.

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