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CD57+ T lymphocytes and functional immune deficiency

Daniele Focosi1, Marco Bestagno, Oscar Burrone

  • 1Division of Hematology, Azienda Ospedaliera Santa Chiara, University of Pisa, via Roma, Pisa, Italy. dfocosi@tin.it

Journal of Leukocyte Biology
|November 3, 2009
PubMed

Insights

CD57 expression on T cells marks cellular aging. This marker is increasingly used to assess immune deficiency in autoimmune diseases, infections, and cancer patients.

Area of Science:

  • Immunology
  • Cellular Biology

Background:

  • CD57 expression on T lymphocytes is a well-established marker for in vitro replicative senescence.
  • Recent research highlights its potential beyond senescence.

Purpose of the Study:

  • To review the literature on CD57(+) T cells.
  • To discuss the clinical implications of CD57 expression as a marker of immune deficiency.

Main Methods:

  • Literature review of studies investigating CD57 expression on T lymphocytes.
  • Analysis of evidence linking CD57 expression to functional immune status.

Main Results:

  • CD57 expression signifies replicative senescence in T cells.
  • Evidence supports CD57 as a marker for immune deficiency in various clinical conditions.

Conclusions:

  • CD57(+) T cells are valuable indicators of immune dysfunction.
  • The utility of CD57 as a clinical biomarker warrants further investigation.

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