Related Experiment Video

Updated: Jun 17, 2026

Multiplex Cyclic Fluorescent Immunohistochemistry
04:21

Multiplex Cyclic Fluorescent Immunohistochemistry

Published on: January 26, 2024

Immunohistochemistry in the diagnosis of cutaneous neoplasms

Mai P Hoang1, Meera Mahalingam, M Angelica Selim

  • 1Harvard Medical School, Massachusetts General Hospital, 55 Fruit Street, Warren 820, Boston, MA 02114, USA. mhoang@partners.org

Future Oncology (London, England)
|December 22, 2009
PubMed

Insights

Diagnostic immunohistochemical stains are increasingly vital for dermatopathology. This review covers current and emerging stains for diagnosing and classifying skin tumors.

Area of Science:

  • Dermatopathology
  • Oncology
  • Immunohistochemistry

Background:

  • Immunohistochemistry (IHC) is crucial in diagnosing and managing skin neoplasms.
  • The availability of diagnostic IHC stains has significantly increased.
  • IHC aids in treatment and prognostication of cutaneous neoplasms.

Purpose of the Study:

  • To review current and novel immunohistochemical stains used in dermatopathology.
  • To outline the relevance of these stains in diagnosing and classifying skin tumors.

Main Methods:

  • Literature review of diagnostic immunohistochemical stains.
  • Focus on stains relevant to cutaneous neoplasms.

Main Results:

  • Significant increase in available diagnostic IHC stains.
  • IHC is indispensable for diagnosis, treatment, and prognosis in dermatopathology.

Conclusions:

  • IHC stains are essential tools for dermatopathologists.
  • Review provides an overview of key stains for skin neoplasm diagnosis and classification.

More Related Videos

Multiplex Immunohistochemical Analysis of the Spatial Immune Cell Landscape of the Tumor Microenvironment06:32

Multiplex Immunohistochemical Analysis of the Spatial Immune Cell Landscape of the Tumor Microenvironment

Published on: August 18, 2023

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Related Concept Videos

Immunocytochemistry and Immunohistochemistry01:22

Immunocytochemistry and Immunohistochemistry

Immunocytochemistry (ICC) and immunohistochemistry (IHC) are techniques that use antibodies to check for specific proteins or antigens in a sample. The technique was first published by Albert Coons in 1941 to detect the presence of pneumococcal antigen in tissue sections from mice infected with Pneumococcus. Immunocytochemistry helps localization of proteins or antigens in individual cells like blood cells, stem cells, etc., while immunohistochemistry does the same for tissue samples.
These...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...