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Updated: Jun 17, 2026
Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays
Published on: March 9, 2017
Development of microfluidic-based heterogeneous immunoassays
Frank Yung Harn Lin1, Yali Gao, Dongqing Li
1Southlake Regional Health Centre, Newmarket, Ontario, Canada. franklin088@yahoo.ca
Insights
This review covers microfluidic immunoassays for biomolecular detection. Future integrated systems promise faster, more efficient diagnostics and drug discovery.
Area of Science:
- Biotechnology
- Analytical Chemistry
- Medical Diagnostics
Background:
- Immunoassays are crucial for detecting biomolecules.
- Microfluidic technology offers miniaturized platforms for assays.
Purpose of the Study:
- To review microfluidic-based heterogeneous immunoassays.
- To discuss microfabrication, surface modification, solution dispensing, and detection technologies.
- To explore applications in biomolecular detection.
Main Methods:
- Review of immunoassay principles.
- Discussion of microfluidic technology and its components.
- Analysis of applications in biomolecular detection.
Main Results:
- Microfluidic platforms enable advanced biomolecular detection.
- Key technologies include microfabrication, surface modification, solution dispensing, and detection.
- Current applications span medical diagnostics, drug discovery, and bioterrorism preparedness.
Conclusions:
- Microfluidic immunoassays are a rapidly developing field.
- Future advancements will focus on integrated, automated systems.
- These systems will reduce assay time and reagent consumption for effective biomolecular detection.
Abstract:
Microfluidic-based heterogeneous immunoassays are reviewed in this article by first introducing the principle of immunoassay, followed by a discussion of microfluidic-based technology. Microfabrication, surface modification, solution dispensing and detection technology are discussed and their applications to biomolecular detection reviewed. In the future, improved manufacturing processes and integrated assay systems in an automatic fashion with a reduced assay time and reagent consumption will allow for the effective detection of biomolecules that are of interest in medical diagnostics, drug discovery and bioterrorism.
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