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CD150 regulates JNK1/2 activation in normal and Hodgkin's lymphoma B cells

Mariya Y Yurchenko1, Larysa M Kovalevska, Larysa M Shlapatska

  • 1Department of Cell Regulation, RE Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, NAS of Ukraine, Kiev, Ukraine.

Immunology and Cell Biology
|March 17, 2010
PubMed

Insights

CD150 receptor signaling impacts MAPK pathways in Hodgkin

Area of Science:

  • Immunology
  • Cell Biology
  • Oncology

Background:

  • CD150 receptor is found on various immune cells and in certain lymphomas.
  • CD150 expression increases during B cell differentiation into plasma cells.

Purpose of the Study:

  • To investigate the role of CD150 signaling in Hodgkin's lymphoma (HL) B cells.
  • To determine how CD150 affects mitogen-activated protein kinase (MAPK) pathways in HL.

Main Methods:

  • Analyzing CD150 expression in primary B cells and HL cell lines.
  • Investigating CD150-mediated phosphorylation of ERK1/2, p38 MAPK, and JNK1/2.
  • Examining the association of CD150 with HPK1 and its effect on JNK phosphorylation.

Main Results:

  • CD150 signaling regulates ERK1/2, p38 MAPK, and JNK1/2 phosphorylation in HL cells.
  • CD150 induces ERK1/2 activation and mediates JNK1/2 activation.
  • CD150 associates with HPK1, enhancing JNK1/2 phosphorylation and inhibiting proliferation.

Conclusions:

  • CD150 signaling modulates MAPK activity in HL tumor cells.
  • CD150 may play a role in regulating tumor cell maintenance in Hodgkin's lymphoma.

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