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A case of candidal umbilical granuloma
A Anstey1, G P Spickett, N Beechey-Newman
1Department of Dermatology, Wycombe General Hospital, U.K.
The British Journal of Dermatology
|May 1, 1991
Insights
A large candidal granuloma was found in a 14-year-old boy. This suggests a specific T-cell defect, a condition often seen in chronic mucocutaneous candidiasis.
Area of Science:
- Immunology
- Dermatology
- Pediatrics
Background:
- Chronic mucocutaneous candidiasis (CMC) is a rare disorder characterized by persistent or recurrent infections of the skin, nails, and mucous membranes with Candida species.
- It is often associated with specific defects in cell-mediated immunity, particularly T-cell dysfunction.
Observation:
- A case study of a 14-year-old male presenting with an umbilical mass.
- The mass was identified as a large, well-organized candidal granuloma.
Findings:
- Immunological workup revealed normal peripheral T and B lymphocyte counts and distribution.
- However, the patient exhibited a lack of reaction to intradermal Candida antigen injection.
- This anergy suggests a specific T-cell defect.
Implications:
- The findings suggest a potential diagnosis of chronic mucocutaneous candidiasis in this patient.
- This case highlights the importance of considering specific T-cell defects in the differential diagnosis of unusual fungal granulomas in pediatric patients.
- Early identification and management of such immune deficiencies are crucial for preventing severe complications.
Abstract:
A case is reported of a 14-year-old boy with a mass arising from the umbilicus, which was a large, well-organized candidal granuloma. Cell markers showed normal numbers and distribution of peripheral T and B lymphocytes but there was no reaction to intradermal injection of Candida, suggesting a specific T-cell defect such as occurs in chronic mucocutaneous candidiasis.
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