[Effect of trauma on space-time organization of B-dependent area of the regional lymph node cortex]

In the experiment performed on 238 non-inbred white mice it has been demonstrated that after trauma in the concha auricularis population density (PD) of immune-competent cells in the germinative center (GC) and in the crown of the regional lymph node (LN) changes. The PD of small lymphocytes increases, and the PD of mitotically dividing cells, immunoblasts, plasmoblasts, immature and mature plasmocytes decreases sharply in both zones. The increase of small lymphocytes PD in the regional LN after the trauma is obviously connected with intensification of their inflow from the lesion focus. Inhibition of proliferation and differentiation of the immune-competent cells in the GC of the crown is a response to the operation stress. During the posttraumatic period both spectral composition and parameters of the constituents of rhythmical alteration of the cells PD change both in the GC and in the crown. As a rule, displacement of acrophase and decrease in amplitude of the rhythm take place. Total power of the process for various types of immune-competent cells alters unequally. In the spectral composition of the rhythmicity amount of circadian components increases, their power increases, too. This demonstrates an increase of central hormonal effects during the posttraumatic period. After trauma fluctuations of the cells PD of the plasmacytic line, as well as in mitotically dividing cells with a 7-hour's period, which has been revealed in intact animals before the trauma, are preserved. This demonstrates a relative independence of the given synchronizer of rhythmicity at a tissue level from any influence of the higher regulatory center.