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CD30-positive anaplastic variant diffuse large B cell lymphoma: a rare case presented with cutaneous involvement
Insights
A rare case of CD30-positive diffuse large B cell lymphoma, anaplastic variant, presented with both lymph node and skin lesions. The patient achieved complete remission with chemotherapy.
Area of Science:
- Hematology
- Oncology
- Dermatology
Background:
- Diffuse large B cell lymphoma (DLBCL) is an aggressive non-Hodgkin lymphoma.
- The anaplastic variant of DLBCL is rare and characterized by specific morphological features.
- CD30 expression can be observed in certain subtypes of DLBCL.
Observation:
- A 67-year-old male presented with cervical lymphadenopathy and tenderness.
- Biopsy revealed pleomorphic large cells positive for CD30, but negative for B and T cell markers.
- Subsequent skin ulceration showed similar atypical cells in the dermis and epidermis.
Findings:
- Immunohistochemistry confirmed CD30, CD45, and PAX5 positivity in lesional cells.
- Absence of CD3, CD10, CD20, CD15, Bcl-2, EBER ISH, EMA, and ALK supported the diagnosis.
- The patient was diagnosed with CD30-positive DLBCL, anaplastic variant, with nodal and cutaneous involvement.
Implications:
- This case highlights a rare presentation of DLBCL, anaplastic variant, with unusual skin involvement.
- The findings underscore the importance of thorough diagnostic workup for atypical lymphoid proliferations.
- Successful treatment with CHOP chemotherapy suggests this regimen may be effective for this rare subtype.
Abstract:
A 67-year-old man suffered from a left cervical lymph node swelling and tenderness. Biopsy of the cervical lymph node showed pleomorphic large cells containing large atypical nuclei. Immunohistochemical stains of these cells were positive for CD30, but negative for CD3 and CD20. After the biopsy, his left cervical skin was ulcerated. Biopsy of the left cervical skin was performed. Large pleomorphic cells with constricted nuclei and Reed-Sternberg-like cells existed in the dermis and epidermis. Immunohistochemical stains of the former cells were positive for CD30, CD45 and PAX5, but negative for CD3, CD10, CD20, CD15, Bcl-2, EBER ISH, EMA and ALK. He was diagnosed with diffuse large B cell lymphoma, anaplastic variant. He achieved complete remission with CHOP chemotherapy. CD30-positive DLBCL, anaplastic variant is a rare B cell lymphoma. Most of the patients presented with primary nodal disease, and skin involvement of lymphoma is very rare. This is the report of a rare case of CD30-positive DLBCL, anaplastic variant, with both nodal and skin lesions.
