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CD200 (OX-2 membrane glycoprotein) expression in b cell-derived neoplasms

David M Dorfman1, Aliakbar Shahsafaei

  • 1Dept of Pathology, Brigham & Women's Hospital, 75 Francis St, Boston, MA 02115, USA. ddorfman@partners.org

American Journal of Clinical Pathology
|October 21, 2010
PubMed

Insights

CD200, a protein, is found in various B-cell cancers, including chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL). This finding suggests CD200 may aid in diagnosing B-cell neoplasms and identify new therapeutic targets.

Area of Science:

  • Immunology
  • Oncology
  • Hematology

Background:

  • CD200 is a membrane glycoprotein belonging to the immunoglobulin superfamily.
  • Its expression patterns in various B-cell malignancies require further elucidation.

Purpose of the Study:

  • To investigate the expression of CD200 in a broad spectrum of B-cell-derived neoplasms.
  • To assess the potential utility of CD200 as an immunophenotypic marker and therapeutic target in these diseases.

Main Methods:

  • Immunohistochemical staining was performed on paraffin-embedded tissue sections.
  • The study analyzed a wide range of B-cell neoplasms.

Main Results:

  • CD200 expression was detected in chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL).
  • Additional B-cell lymphoproliferative disorders, including hairy cell leukemia and classical Hodgkin lymphoma, showed CD200 immunoreactivity.
  • Neoplastic cells in B-lymphoblastic leukemia/lymphoma also expressed CD200.

Conclusions:

  • CD200 may serve as a valuable immunophenotypic marker for evaluating B-cell-derived neoplasms.
  • The expression of CD200 in various B-cell malignancies suggests potential therapeutic applications for anti-CD200 immunotherapeutic agents currently in clinical trials.

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