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Myeloma-related disorder with leukaemic progression in a cat
Yoshinori Takeuchi1, Haruna Iizuka, Hiroyuki Kanemitsu
1Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
Insights
A feline myeloma-related disorder (MRD) case showed leukaemic progression. This aggressive plasma cell cancer in cats proved unresponsive to standard chemotherapy, leading to a fatal outcome.
Area of Science:
- Veterinary Medicine
- Oncology
- Hematology
Background:
- Feline myeloma-related disorder (MRD) is a rare neoplastic condition.
- Diagnosis and treatment of aggressive plasma cell malignancies in cats remain challenging.
Observation:
- A 10-year-old American Shorthair cat presented with anorexia, weight loss, and nasal discharge.
- Clinical examination revealed pancytopenia and hyperproteinaemia.
- Bone marrow aspirates showed 50% atypical plasma cells, with progressive peripheral blood increase over 64 days.
Findings:
- The cat's condition was diagnosed as myeloma-related disorder (MRD) with leukaemic progression.
- Chemotherapy with melphalan, chlorambucil, and prednisolone was ineffective.
- The patient succumbed to the disease 71 days post-initial presentation.
Implications:
- This case highlights the aggressive nature and poor prognosis of leukaemic MRD in cats.
- It underscores the need for further research into novel therapeutic strategies for feline plasma cell neoplasms.
- Accurate diagnosis and understanding disease progression are crucial for managing feline MRD.
Abstract:
A 10-year-old American Shorthair cat with nasal discharge, anorexia, and weight loss was found to have pancytopenia and hyperproteinaemia. Bone marrow aspiration revealed atypical plasma cells that totalled 50% of the nucleated bone marrow cells. The number of atypical plasma cells progressively increased in the peripheral blood during the observation period of 64 days. The cat did not respond to treatments with melphalan, chlorambucil, and prednisolone, and died 71 days after the initial presentation. Clinical, cytological, histopathological, and immunohistochemical findings in this case supported the diagnosis of myeloma-related disorder (MRD) with leukaemic progression.
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