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Published on: January 14, 2014
Primary intracerebral Hodgkin lymphoma with recurrence
W-C Foo1, A Desjardins, T J Cummings
1Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA. foo00001@mc.duke.edu
Insights
This case report details an immunocompetent male with primary intracerebral Hodgkin lymphoma. The aggressive brain tumor recurred, presenting a rare clinical challenge for oncologists.
Area of Science:
- Neurology
- Oncology
- Pathology
Background:
- Primary intracerebral Hodgkin lymphoma is exceedingly rare.
- Intracranial lymphomas typically present as diffuse large B-cell lymphomas, not classical Hodgkin lymphoma.
- Limited data exists on the behavior and management of primary intracerebral Hodgkin lymphoma.
Objective:
To report a case of primary intracerebral Hodgkin lymphoma with disease recurrence.
Methods:
Case report and review of the literature.
Results:
A 58-year-old immunocompetent male presented with aphasia. Neuroimaging revealed a left temporal lobe lesion. A craniotomy and resection were performed, and the diagnosis of classical Hodgkin lymphoma was made. Systemic work-up for lymphoma was negative. Postoperatively, the patient was treated with whole brain irradiation. 14 months later, the patient developed an enhancing lesion in his pons and received combination chemotherapy and radiation therapy. Repeat imaging demonstrated leptomeningeal enhancement and multiple lesions throughout the cerebral hemispheres, cerebellum and brainstem.
Comment:
We report what appears to be the first case of a patient with aggressive primary intracerebral Hodgkin lymphoma with disease recurrence.
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