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C1q nephropathy presenting as acute renal failure

Pavan Malleshappa1, Ravi Ranganath, Anup P Chaudhari

  • 1Department of Nephrology, Lilavati Hospital and Research Centre, Mumbai, India. dr_pavanm@yahoo.co.in

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
|March 23, 2011
PubMed

Insights

C1q nephropathy, a kidney disease, can cause acute renal failure. This case study shows that intensive steroid treatment effectively resolved proteinuria and achieved remission in a patient with C1q nephropathy.

Area of Science:

  • Nephrology
  • Immunopathology

Background:

  • C1q nephropathy is a rare glomerular disease characterized by C1q deposition in the kidney.
  • It can present with nephrotic syndrome or acute kidney injury, often mimicking other glomerulonephritides.

Observation:

  • A 42-year-old male presented with high-grade fever and acute renal failure necessitating hemodialysis.
  • Renal biopsy showed focal proliferative glomerulonephritis with dominant mesangial C1q deposition and electron-dense deposits.

Findings:

  • The patient was diagnosed with C1q nephropathy, excluding systemic lupus erythematosus.
  • Treatment with methylprednisolone pulse and oral prednisolone resulted in complete remission and proteinuria resolution.

Implications:

  • This case highlights the efficacy of intensive immunosuppressive therapy in managing C1q nephropathy.
  • Early diagnosis and prompt treatment may improve renal outcomes in C1q nephropathy patients.

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