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Published on: April 11, 2019
Electroconvulsive therapy in single manic episodes: a case series
H Mohammadbeigi1, S Alizadegan, M Barekatain
1Department of Psychiatry, Isfahan University of Medical Sciences, Isfahan, Iran.
Insights
Electroconvulsive therapy (ECT) is an effective and safe treatment for bipolar I disorder patients experiencing a single manic episode. Early initiation of ECT can improve patient outcomes, even in first-episode mania.
Area of Science:
- Psychiatry
- Neurology
Background:
- Bipolar I Disorder is a severe mental health condition characterized by manic episodes.
- Treatment options for manic episodes include pharmacotherapy and electroconvulsive therapy (ECT).
Purpose of the Study:
- To evaluate the effectiveness and safety of electroconvulsive therapy (ECT) for patients with Bipolar I Disorder presenting with a single manic episode.
Main Methods:
- A retrospective study analyzed medical records of inpatients with a single manic episode of Bipolar I Disorder.
- Data were collected from Noor University Hospital, Iran, between September 2004 and December 2008.
Main Results:
- Out of 275 patients, 39 received ECT. Patients receiving ECT were younger and had a longer length of stay compared to those treated solely with medication.
- ECT significantly reduced the need for chemical and physical restraints (77% to 7.7%).
- Catatonia and aggressive behavior were primary indications for ECT.
Conclusions:
- Electroconvulsive therapy (ECT) is an effective and safe treatment for single manic episodes in Bipolar I Disorder.
- Consideration should be given to reducing the time to ECT initiation, even for first-episode mania.
Objective:
To evaluate the effectiveness of electroconvulsive therapy in the treatment of Bipolar I Disorder patients with a single manic episode.
Method:
In a retrospective study, we reviewed medical records of inpatients who had been admitted to treat a single manic episode of Bipolar I Disorder at Noor University Hospital, Isfahan, Iran between September 2004 and December 2008.
Results:
Out of a total of 275 single episode manic patients, 39 underwent ECT. Male/female ratios were 19/20 (48.7% vs. 51.3%) for the ECT series and 137/99 (58% vs. 42%) for the exclusive pharmacological treatment series (p>0.05). Mean age of patients in the ECT series (23.64 ± 8.00) was significantly lower than the pharmacological treatment series (27.65 ± 11.30, p = 0.008). The mean length of stay (LOSs) for the ECT series (20.0 ± 7.90) was significantly higher than the other group (14.63 ± 9.84, p = 0.001). The mean time to first administered ECT (tECT) was 4.35 ± 3.79. There was no significant difference between the mean LOSs of the pharmacologic treatment series and the mean "LOSs minus tECT" (LOS-tECT) variable (16.57 ± 8.43) in the ECT series (p>0.05). The mean duration from the onset of the symptoms to time of admission was 19.22 ± 3.53 for the ECT series. Catatonia was the indication for application of ECT in one patient (2.6%), while 25 (64.10%) received ECT because of aggressive behavior. The proportion of patients administered chemical and physical restraints before ECT (77%) significantly dropped (7.7%) after ECT administration (p<0.001).
Conclusion:
ECT is an effective, safe, and probably underused treatment method for single episode manic patients. Reducing the time until commencement of ECT should be considered, even in a single manic episode.
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