CD8+ Lymphomatoid Papulosis
1Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.
Insights
This report details a rare case of CD8 positive lymphomatoid papulosis (LyP), a condition typically characterized by CD4 expression. The findings contribute to understanding variations in this clinically benign skin disorder.
Area of Science:
- Dermatopathology
- Immunohistochemistry
- Oncology
Background:
- Lymphomatoid papulosis (LyP) is a rare skin condition with malignant histology but benign clinical behavior.
- Typical immunophenotyping of LyP lesions shows CD4 positivity and CD8 negativity.
- CD8 positive LyP is an uncommon variant requiring careful diagnostic consideration.
Observation:
- A 43-year-old male presented with asymptomatic erythematous papules on his axilla and thigh.
- Histopathology revealed a wedge-shaped infiltrate with atypical lymphoid cells.
- Immunophenotyping demonstrated neoplastic cells positive for CD3, CD8, and CD30, and negative for CD4, CD20, and CD56.
Findings:
- This case represents a rare instance of CD8 positive lymphomatoid papulosis.
- The immunophenotype contrasts with the more common CD4 positive LyP.
- The presence of CD8 positivity in LyP expands the known spectrum of this condition.
Implications:
- Highlights the importance of comprehensive immunophenotyping in diagnosing LyP variants.
- Contributes to the literature on CD8 positive LyP, aiding future research.
- May influence diagnostic criteria and understanding of LyP pathogenesis.
Abstract:
Lymphomatoid papulosis (LyP) is defined as a histologically malignant, but clinically benign condition. It can appear as erythematous pink to purple papules or nodules. Immunophenotyping studies of the lymphomatoid papulosis lesions have shown a predominance of a CD4 expression and negativity for CD8. However, a positive CD8 expression has rarely been reported for LyP. Herein we report on a case of CD8 positive lymphomatoid papulosis in a 43-year-old man. The patient presented with erythematous, asymptomatic papules on the left axilla and thigh. Histopathologically, there was a wedge-shaped infiltrate composed of a mixture of various cell types, including lymphocytes, histiocytes, neutrophils and large atypical lymphoid cells. Immunophenotyping revealed the neoplastic cells were positive for CD3, CD8 and CD30 and they were negative for CD4, CD20 and CD56.
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