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Platform for Quantitative Detection of Endometrial Immune Cells Based on Immunohistochemistry and Digital Image Analysis
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Platform for Quantitative Detection of Endometrial Immune Cells Based on Immunohistochemistry and Digital Image Analysis

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Immunohistochemistrical and clinicopathological characterization of chronic endometritis

Kotaro Kitaya1, Tadahiro Yasuo

  • 1Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Kajii-cho, Kamigyo-ku, Japan. kitaya@koto.kpu-m.ac.jp

American Journal of Reproductive Immunology (New York, N.Y. : 1989)
|July 14, 2011
PubMed

Insights

Chronic endometritis, a common gynecological condition, is often asymptomatic and difficult to detect. Immunohistochemistry revealed its prevalence and highlighted differences between symptomatic and asymptomatic cases.

Area of Science:

  • Gynecologic pathology
  • Reproductive immunology

Background:

  • Chronic endometritis is often asymptomatic and challenging to diagnose with conventional methods.
  • Immunohistochemistry offers a more sensitive approach to identifying this condition.

Purpose of the Study:

  • To investigate the clinicopathological features of chronic endometritis using immunohistochemistry.
  • To determine the prevalence and characteristics of chronic endometritis in endometrial specimens.

Main Methods:

  • Immunohistochemistry for syndecan-1 (a plasmacyte marker) was performed on 234 archival endometrial specimens.
  • Endometrial morphology was dated, and stromal plasmacyte infiltration was quantified.
  • Clinical data from patient charts were correlated with pathological findings.

Main Results:

  • Chronic endometritis was detected in 11.1% of examined samples.
  • The condition occurred equally in proliferative and secretory phases.
  • 23.1% of cases were asymptomatic, with less pronounced stromal infiltration and morphological delay compared to symptomatic cases.

Conclusions:

  • Chronic endometritis is a prevalent gynecological condition, frequently asymptomatic.
  • No significant menstrual cycle-dependent variation in chronic endometritis occurrence was observed.
Abstract

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