Related Experiment Video
Updated: May 30, 2026

Efficacy of Fu's Subcutaneous Needling on Sciatic Nerve Pain: Behavioral and Electrophysiological Changes in a Chronic Constriction Injury Rat Model
Published on: June 30, 2023
[Automated intermittent bolus infusion for continuous sciatic nerve block: a case report]
Atsushi Hashimoto1, Hiroshi Ito, Yuko Sato
1Department of Anesthesiology, Aichi Medical University, Aichi 480-1195.
Insights
Automated intermittent bolus infusion for sciatic nerve blocks effectively managed severe pain in critical limb ischemia (CLI) patients unresponsive to continuous infusion. This technique offers improved analgesia for refractory CLI pain.
Area of Science:
- Anesthesiology
- Pain Management
- Vascular Surgery
Background:
- Critical limb ischemia (CLI) often causes severe, refractory pain.
- Systemic analgesics and conventional nerve blocks may be insufficient for CLI pain management.
Observation:
- Two cases of CLI with severe lower extremity pain are presented.
- Case 1: Ultrasound-guided popliteal nerve catheter with automated intermittent bolus infusion of ropivacaine provided effective analgesia.
- Case 2: Automated intermittent bolus infusion via popliteal sciatic nerve block provided inadequate pain relief despite previous interventions.
Findings:
- Automated intermittent bolus infusion via peripheral nerve catheter demonstrated variable efficacy in managing severe CLI pain.
- Patient-controlled analgesia with intermittent bolus infusions may offer superior pain control compared to continuous infusions in select CLI patients.
Implications:
- Automated intermittent bolus infusion represents a potential alternative for managing refractory ischemic pain in CLI.
- Further research is warranted to optimize patient selection and protocols for this analgesic technique in CLI.
- This approach may improve quality of life for patients suffering from severe ischemic limb pain.
Abstract:
We present two cases of severe pain due to critical limb ischemia (CLI) treated with automated intermittent bolus infusion for continuous sciatic nerve blocks. Case 1: A 32-year-old man had severe lower extremity ischemic pain due to Fontaine grade IV peripheral vascular disease. The pain did not respond to systemic analgesics. A popliteal nerve catheter was placed under ultrasound guidance. After confirming the effect of continuous infusion of ropivacaine from the catheter unsatisfactory, automated intermittent with patient-controlled bolus administration was started. His pain was controlled well. Case 2: A 52-year-old man had severe foot pain due to Buerger's disease. Bypass surgery and angioplasty failed to improve his symptoms. Even after the amputation of superficial fibular nerve, deep fibular nerve and tibial nerve, his pain persisted. The continuous popliteal sciatic nerve block was started. As continuous infusion did not relieve his pain, automated intermittent with patient-controlled bolus administration was started. However even with this technique, his pain was not relieved well. In some patients whose severe pain due to CLI could not be managed well, automated intermittent bolus infusion of local anesthetics from peripheral nerve catheter may provide better analgesia than continuous infusion.
Related Concept Videos
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
One of the advantages of...
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions
Drug Delivery: Parenteral Route
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
