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Cleaved and multilobated cell immunocytoma of low grade malignancy with amyloid. An immunohistochemical and electron
Insights
This study describes a rare immunocytoma variant mimicking lymphoma, characterized by amyloid deposits and specific immunoglobulin features. Chemotherapy induced a morphological shift to typical lymphoplasmacytoid immunocytoma.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Immunocytoma is a B-cell malignancy.
- Low-grade lymphomas can present with varied cytological features.
- Amyloid deposition is an uncommon finding in immunocytoma.
Abstract:
An unusual variant of immunocytoma of low grade malignancy, cytologically resembling follicular cleaved-cell malignant lymphoma is described. Presence of heavy deposits of amyloid, intracytoplasmic monoclonal IgM-kappa immunoglobulin, cells with Dutcher inclusions, electron-microscopic features and negativity of T-cell markers led to diagnosis of immunocytoma. After cytostatic chemotherapy the lymphoma changed its morphology into typical lymphoplasmacytoid immunocytoma.
