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Primary intracerebral plasma cell granuloma: a light, immunocytochemical, and ultrastructural study of one case
D Figarella-Branger1, D Gambarelli, M Perez-Castillo
1Department of Neuropathology, Centre Hospitalier Regional, Marseille, France.
Insights
This study presents a rare case of primary intracerebral plasma cell granuloma. The lesion exhibited distinct central fibrous histiocytoma and peripheral plasma cell patterns, with confirmed histiocytic cells.
Area of Science:
- Neuropathology
- Oncology
- Histopathology
Background:
- Primary intracerebral plasma cell granuloma is an exceptionally rare central nervous system (CNS) tumor.
- This case presents a unique instance without meningeal involvement, highlighting its distinct characteristics.
Observation:
- Histological examination revealed a biphasic pattern: a central benign fibrous histiocytoma and a peripheral inflammatory infiltrate.
- The peripheral infiltrate comprised polyclonal plasma cells, lymphocytes, and cells with epithelial-like morphology.
Findings:
- Immunocytochemistry and electron microscopy confirmed the histiocytic origin of the 'epithelial-like' cells.
- The findings suggest a complex histogenesis involving reactive cellular components within the brain parenchyma.
Implications:
- Understanding the histogenesis and differential diagnosis of such rare CNS lesions is crucial for accurate diagnosis.
- This case contributes to the limited literature on intracerebral plasma cell granulomas, aiding future research and clinical management.
Abstract:
A case of primary intracerebral plasma cell granuloma without meningeal attachment is presented. Histologically, the lesion showed two different patterns. At the center, it displayed the features of a benign fibrous histiocytoma. At the periphery, a mixture of polyclonal plasma cells, lymphocytes, and "epithelial-like" cells was observed. Electron microscopy and immunocytochemistry confirmed the histiocytic nature of the "epithelial-like cells." The differential diagnosis and histogenesis of such a lesion are discussed.