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EEG recordings following intrathecal iohexol administration
V E Drory1, E Avrahami, M Y Neufeld
1Department of Neurology, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Israel.
Insights
Iohexal (Omnipaque) demonstrated safety in patients undergoing spinal imaging. Electroencephalogram (EEG) monitoring revealed no adverse neurological effects after intrathecal administration, suggesting it is a safer contrast agent.
Area of Science:
- Neuroradiology
- Neurophysiology
- Pharmacology
Background:
- Intrathecal contrast agents are used in neuroimaging.
- Previous contrast media, like metrizamide, have shown encephalopathic effects.
- Evaluating the safety of newer contrast agents is crucial.
Purpose of the Study:
- To assess the encephalopathic potential of iohexal (Omnipaque) after intrathecal administration.
- To compare the safety profile of iohexal with other commonly used contrast agents.
Main Methods:
- Electroencephalogram (EEG) recordings were obtained from 30 patients.
- Recordings were taken before, several hours after, and 24 hours after intrathecal iohexal administration.
- Procedures included cervical myelography and cisternography.
Main Results:
- No EEG abnormalities were detected in any patient post-administration.
- Iohexal did not induce significant neurological changes detectable by EEG.
- The contrast medium was well-tolerated.
Conclusions:
- Iohexal is a safe intrathecal contrast medium.
- Iohexal exhibits fewer encephalopathic effects compared to metrizamide.
- This suggests iohexal is a favorable alternative for spinal imaging procedures.
Abstract:
Electroencephalogram (EEG) recordings were performed before and after intrathecal administration of iohexal (Omnipaque) in 30 patients who underwent cervical myelography or cisternography. Tracings were recorded before, several hours after, and 24 h after iohexol administration. No abnormalities were recorded. It can be concluded that iohexol is a safe contrast medium, having less encephalopathic effects than more commonly used substances such as metrizamide.