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Type 2 myocardial infarction following generalized tonic-clonic seizure

Jinkyu Park1, Jeong Hun Shin, Seok Hwan Kim

  • 1Division of Cardiology, Department of Internal Medicine, Hanyang University Medical Center, Seoul, Korea.

Korean Circulation Journal
|December 24, 2011
PubMed

Insights

Elevated troponin I levels, a marker of heart damage, can occur after a generalized tonic-clonic seizure. This case highlights type 2 myocardial infarction as a potential diagnosis following seizures.

Area of Science:

  • Cardiology
  • Neurology
  • Biomarkers

Background:

  • Myocardial infarction (MI) diagnosis relies on elevated cardiac biomarkers during acute myocardial ischemia.
  • Troponin I is a highly specific and preferred biomarker for detecting myocardial necrosis.
  • MI following seizures is uncommon, making such cases noteworthy.

Purpose of the Study:

  • To report a case of elevated troponin I levels in a patient subsequent to a generalized tonic-clonic seizure.
  • To investigate the potential link between seizures and myocardial injury.
  • To consider type 2 myocardial infarction in the differential diagnosis after seizure events.

Main Methods:

  • Clinical assessment of a patient presenting with symptoms and history of a generalized tonic-clonic seizure.
  • Measurement of cardiac biomarker levels, specifically troponin I.
  • Diagnostic evaluation for acute coronary syndromes and other potential causes of troponin elevation.

Main Results:

  • The patient exhibited elevated troponin I levels post-seizure.
  • The clinical presentation and biomarker profile were consistent with myocardial injury.
  • The diagnosis of type 2 myocardial infarction was established.

Conclusions:

  • Generalized tonic-clonic seizures can be associated with elevated troponin I levels.
  • Type 2 myocardial infarction should be considered in patients with elevated troponin I after a seizure.
  • This case underscores the importance of comprehensive evaluation in seizure patients with cardiac biomarker abnormalities.

Keywords:
Coronary angiographyEpilepsyMyocardial infarctionTroponin I

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