Related Experiment Video
Updated: May 25, 2026

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
Published on: May 3, 2021
Amputation for histiocytic sarcoma in a cat
Takahiro Teshima1, Takashi Hata, Yoko Nezu
1Division of Veterinary Internal Medicine, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan. teshima63@nvlu.ac.jp
Insights
This study reports a rare feline histiocytic sarcoma in a cat. Despite amputation, the cancer recurred, leading to euthanasia, highlighting challenges in treating this aggressive tumor.
Area of Science:
- Veterinary Medicine
- Oncology
- Dermatology
Background:
- Histiocytic sarcoma is an uncommon and aggressive tumor in cats.
- Cutaneous manifestations can be the primary presentation of histiocytic sarcoma.
- Treatment options and outcomes for feline histiocytic sarcoma are not well-established.
Observation:
- A 9-year-old domestic shorthair cat presented with a tarsal skin lesion.
- Histopathological and immunohistochemical analysis confirmed histiocytic sarcoma.
- Surgical amputation of the affected limb was performed.
Findings:
- Postoperative improvement was noted, but skin lesions recurred within 44–60 days.
- Relapse occurred at multiple sites, including the amputation site.
- Euthanasia was elected due to disease progression.
Implications:
- This case is the first report of feline histiocytic sarcoma treated with amputation.
- Amputation alone may not be sufficient for managing feline histiocytic sarcoma.
- Highlights the need for understanding the aggressive behavior and exploring alternative therapies for this rare feline cancer.
Abstract:
A 9-year-old spayed female domestic shorthair cat presented with a skin lesion of the left tarsus. The lesion was biopsied and, based on the microscopic appearance and immunohistochemical characteristics, histiocytic sarcoma was diagnosed. Amputation was performed with improved demeanor seen postoperatively. However, between 44 and 60 days following the surgery, relapse of skin lesions appeared in multiple locations, including at the previous amputation site, and euthanasia was elected. This is the first report of a histiocytic sarcoma treated with amputation in a cat.
