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Follicular immunoblastic lymphoma: neoplastic counterpart of the intrafollicular immunoblast?
Pathology
|April 1, 1990
Insights
This study reports a rare follicular lymphoma case composed of immunoblasts with plasmacytoid features. We suggest this represents a neoplastic form of intrafollicular immunoblasts found in lymphoid tissue.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- B-immunoblasts are precursors to plasma cells.
- Typically found in interfollicular regions of lymphoid tissue.
- Small numbers of intrafollicular immunoblasts also exist.
Abstract:
B-immunoblasts, the precursors of plasma cells, occur predominantly in the interfollicular regions of lymphoid tissue, but may also occur in small numbers in germinal centres (intrafollicular immunoblasts). We report an unusual case of de novo follicular lymphoma composed of immunoblasts with an appreciable amount of plasmacytoid cytoplasm. We postulate that follicular immunoblastic lymphoma probably represents the neoplastic counterpart of the intrafollicular immunoblast.