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Human leucocyte differentiation antigens: review of the CD nomenclature

W N Erber1

  • 1Hematology Department, Royal North Shore Hospital, Sydney.

Pathology
|April 1, 1990
PubMed

Insights

The 4th International Workshop on Human Leucocyte Differentiation Antigens updated the CD nomenclature, defining 78 clusters. New insights into antigen structure, function, and molecular genetics were presented.

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Genetics

Background:

  • The 4th International Workshop and Conference on Human Leucocyte Differentiation Antigens convened in Vienna in February 1989.
  • This workshop focused on reviewing the structure and function of known cellular antigens and defining new ones.

Purpose of the Study:

  • To discuss new information on the structure and function of leucocyte antigens presented at the workshop.
  • To outline newly defined CD (clusters of differentiation) clusters and revisions to established ones.

Main Methods:

  • Review of recognized cellular antigens.
  • Definition of new antigens.
  • Gene cloning and sequencing for molecular genetics insights.

Main Results:

  • The CD nomenclature was extended to a total of 78 CD clusters.
  • Some previously described CD groups were revised and sub-divided.
  • New information on antigen structure, function, and molecular genetics was obtained.

Conclusions:

  • The workshop significantly advanced the understanding and classification of human leucocyte differentiation antigens.
  • The extended CD nomenclature provides a more comprehensive framework for immunological research.

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