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Homeostatic and innate immune responses: role of the transmembrane glycoprotein CD98

Hang Thi Thu Nguyen1, Didier Merlin

  • 1M2iSH, UMR 1071 Inserm, University of Auvergne, Clermont-Ferrand, 63000, France, hang.nguyen@u-clermont1.fr.

Cellular and Molecular Life Sciences : CMLS
|March 31, 2012
PubMed

Insights

The transmembrane glycoprotein CD98 regulates cell functions and immune responses. Its abnormal expression is linked to diseases, making CD98 a therapeutic target for inflammation and cancer.

Area of Science:

  • Cellular Biology
  • Immunology
  • Molecular Medicine

Background:

  • Transmembrane glycoprotein CD98 (also known as SLC3A2) is crucial for cell functions.
  • CD98 regulates integrin signaling and amino acid transport.
  • Dysfunctional CD98 impacts cell homeostasis and immune responses, correlating with diseases like inflammation and tumor metastasis.

Purpose of the Study:

  • To review the multifaceted role of CD98.
  • To highlight its functional importance in maintaining homeostasis and immune responses.
  • To provide insights into CD98-associated disease pathogenesis.

Main Methods:

  • Literature review of studies on CD98.
  • Analysis of CD98's involvement in cellular processes.
  • Examination of CD98's correlation with disease states.

Main Results:

  • CD98 is a key regulator of integrin signaling and amino acid transport.
  • Abnormal CD98 expression or function leads to cellular defects.
  • CD98 expression is associated with inflammatory conditions and tumor metastasis.

Conclusions:

  • CD98 plays a vital role in cell homeostasis and immunity.
  • Targeting CD98 offers a potential therapeutic strategy for various diseases.
  • Understanding CD98's function is critical for disease treatment and prevention.

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