Related Experiment Video
Updated: May 21, 2026

Application of the En Bloc Concept Combined with Anatomic Resection in Laparoscopic Hepatectomy
Published on: March 10, 2023
Lymphoid hyperplasia detected as a single mass in the gallbladder: report of a case
Satoshi Yamamoto1, Tadashi Tsukamoto, Akishige Kanazawa
1Department of Hepato-Biliary-Pancreatic Surgery, Osaka City General Medical Hospital, 2-13-22 Miyakojima Hondori, Miyakojima-ku, Osaka 534-0021, Japan. satoshi.hbps@gmail.com
Insights
This case report details rare gallbladder lymphoid hyperplasia, presenting unique imaging findings on CT and ultrasound. Diagnosis was confirmed after laparoscopic cholecystectomy, revealing normal lymphocytes and lymph follicles.
Area of Science:
- Gastroenterology
- Pathology
- Radiology
Background:
- Gallbladder masses require careful differential diagnosis.
- Lymphoid hyperplasia is an uncommon finding in the gallbladder.
Observation:
- A 42-year-old female presented with a gallbladder neck mass.
- Imaging revealed atypical features, and tumor markers were normal.
- Laparoscopic cholecystectomy was performed due to indeterminate diagnosis.
Findings:
- Macroscopic examination showed a submural tumor with a clear border.
- Microscopic analysis identified numerous lymph follicles with germinal centers in the subserosal layer.
- The final diagnosis was lymphoid hyperplasia with chronic cholecystitis.
Implications:
- This case highlights the importance of considering rare diagnoses in gallbladder pathology.
- Unique imaging characteristics of gallbladder lymphoid hyperplasia are presented.
- Further research may elucidate the pathogenesis and clinical significance of this rare condition.
Abstract:
We herein report a case of lymphoid hyperplasia of the gallbladder that showed unique images on computed tomography and ultrasonography. A 42-year-old female was referred to our hospital for evaluation and treatment of a gallbladder tumor. Ultrasonography and computed tomography showed a mass in the wall of the gallbladder neck, without typical findings of benign or malignant tumors. The serum levels of tumor markers, such as carcinoembryonic antigen, carbohydrate antigen 19-9, alpha-fetoprotein, and cytokeratin 19 fragment, were all within normal limits. Laparoscopic cholecystectomy was therefore performed. There were no stones in the gallbladder. Macroscopically, the submural tumor had a clear border without a capsule and a cystic portion. Its cut surface was grayish white. Microscopically, many lymph follicles with germinal centers were recognized in the subserosal layer. The lymphocytes were morphologically normal. We diagnosed lymphoid hyperplasia with chronic cholecystitis. Lymphoid hyperplasia of the gallbladder is extremely rare.
Related Concept Videos
Gallbladder
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins the common...
Cholecystitis
Appendicitis