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MYC rearrangement involving a novel non-immunoglobulin chromosomal locus in precursor B-cell acute lymphoblastic

Ja-Young Seo1, Soo Hyun Lee, Hee-Jin Kim

  • 1Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Annals of Laboratory Medicine
|July 11, 2012
PubMed

Insights

This study reports the first case of MYC rearrangement with a non-immunoglobulin partner in precursor B-cell acute lymphoblastic leukemia (ALL). This finding expands our understanding of genetic abnormalities in ALL.

Area of Science:

  • Hematology
  • Oncology
  • Genetics

Background:

  • MYC rearrangement is a hallmark of Burkitt lymphoma and some mature B-cell neoplasms, usually involving immunoglobulin gene partners.
  • Precursor B-cell acute lymphoblastic leukemia (ALL) is a distinct hematologic malignancy.

Observation:

  • A 4-year-old Korean boy with precursor B-cell ALL presented with a novel MYC rearrangement at second relapse.
  • Cytogenetic analysis identified a t(4;8)(q31.1;q24.1) translocation, confirmed as a MYC rearrangement via FISH.
  • The patient did not achieve remission and died 3 months post-relapse.

Findings:

  • This case represents the first documented instance of a MYC rearrangement with a non-immunoglobulin partner in precursor B-cell ALL.
  • The identified translocation involved chromosome 8, locus q24.1, where the MYC gene is located.

Implications:

  • This discovery broadens the spectrum of known genetic alterations in precursor B-cell ALL.
  • Understanding novel MYC rearrangement partners may offer new insights into ALL pathogenesis and potential therapeutic targets.

Keywords:
MYC gene rearrangementNon-immunoglobulin partnerPrecursor B-cell acute lymphoblastic leukemia

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